IONIS PHARMACEUTICALS INC (IONS)

NASDAQ · Pharmaceuticals & Biotech · Pharmaceutical Preparations

Price

$43.93

Day

-3.98%

Market cap

$7.3B

Close 2026-09-23.

The company

Overview For three decades, we have invented medicines that bring better futures to people with serious diseases. As a pioneer in RNA-targeted medicines with a deep understanding of disease biology and an industry-leading drug discovery technology, we are driven to deliver innovative, life-changing advances for patients. In the last year, we delivered on our strategy to create accelerating value for all our stakeholders. With two independent commercial launches now underway, we transitioned into a fully integrated commercial-stage biotechnology company. We currently have seven marketed medicines to treat serious diseases: TRYNGOLZA (olezarsen), DAWNZERA (donidalorsen), WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen).

From Item 1: Overview.

Institutional holders

Largest positions reported on Form 13F for the quarter ended 2026-06-30, by value.

• Capital World Investors — $1.72B
• FMR LLC — $1.06B
• FMR LLC — $890.58M
• VANGUARD PORTFOLIO MANAGEMENT LLC — $623.18M
• VANGUARD CAPITAL MANAGEMENT LLC — $571.8M
• WELLINGTON MANAGEMENT GROUP LLP — $558.24M
• TWO SIGMA INVESTMENTS, LP — $495.75M
• BlackRock, Inc. — $359.04M

Insider trades

Open-market buys and sales filed on Form 4, newest first. Grants, option exercises and tax withholding are left out.

• Hayden Michael R (Director) bought 5,000 shares at $51.60 on 2026-07-31
• Hayden Michael R (Director) bought 15,000 shares at $53.38 on 2026-07-30
• BENNETT C FRANK (EVP, Chief Scientific Officer) sold 5,536 shares at $83.58 on 2026-07-07
• BENNETT C FRANK (EVP, Chief Scientific Officer) sold 15,000 shares at $85.46 on 2026-07-07
• Diaz Allene M. (Director) sold 10,111 shares at $85.42 on 2026-07-07
• Kordasiewicz Holly B. (EVP, Chief Development Officer) sold 362 shares at $84.30 on 2026-07-07

Recent filings

• 8-K — 2026-09-04
• 8-K — 2026-09-04
• 4 — 2026-09-02
• 4 — 2026-09-02
• 4 — 2026-09-02
• 4 — 2026-09-02
• 4 — 2026-07-31
• S-8 — 2026-07-31
• 10-Q — 2026-07-29
• 8-K — 2026-07-29