GYRE THERAPEUTICS, INC. (GYRE)
NASDAQ · Pharmaceuticals & Biotech · Pharmaceutical Preparations
- Price
- $7.40
- Day
- -1.20%
- Market cap
- $825.17M
Close 2026-09-23.
The company
Overview We are a commercial-stage biopharmaceutical company focused on the development and commercialization of small-molecule therapies for the treatment of organ fibrosis and inflammatory diseases. We operate through our majority indirectly owned subsidiary, Gyre Pharmaceuticals, in the PRC, and through our U.S. operations headquartered in San Diego, California. In the PRC, we have established a strong commercial and operational foundation in fibrotic diseases through the successful development and commercialization of ETUARY® (pirfenidone), which has generated consistent revenue and positioned us as a leading participant in the treatment of pulmonary fibrosis. Fibrotic diseases affect large patient populations worldwide and involve complex, multi-stage biological processes driven by multiple molecular pathways. Given this complexity, therapies that modulate key profibrotic signaling pathways may offer meaningful clinical benefit; however, effective treatment may require targeting mechanisms across different stages of disease progression. Building on our commercialization experience and infrastructure in the PRC, we have expanded our presence into the United States to advance the clinical development of our innovative pipeline, including F351 (Hydronidone), our lead product candidate for liver fibrosis.
From Item 1: Overview.
Institutional holders
Largest positions reported on Form 13F for the quarter ended 2026-06-30, by value.
- HSG Holding Ltd — $24.71M
- Octagon Capital Advisors LP — $6.29M
- VANGUARD CAPITAL MANAGEMENT LLC — $5.78M
- BlackRock, Inc. — $3.68M
- GEODE CAPITAL MANAGEMENT, LLC — $3.01M
- BlackRock, Inc. — $2.21M
- STATE STREET CORP — $1.62M
- CHARLES SCHWAB INVESTMENT MANAGEMENT INC — $1.21M
Insider trades
Open-market buys and sales filed on Form 4, newest first. Grants, option exercises and tax withholding are left out.
- Ye Weiguo (Chief Operating Officer) sold 3,000 shares at $6.35 on 2026-06-18
- Ye Weiguo (Chief Operating Officer) sold 2,800 shares at $6.17 on 2026-06-11
- Ye Weiguo (Chief Operating Officer) sold 5,000 shares at $6.24 on 2026-06-10
- Ye Weiguo (Chief Operating Officer) sold 6,418 shares at $6.21 on 2026-06-10
- Ye Weiguo (Chief Operating Officer) sold 3,000 shares at $6.15 on 2026-06-09
- Ye Weiguo (Chief Operating Officer) sold 14,500 shares at $6.14 on 2026-06-09
Recent filings
- 8-K — 2026-09-01
- S-8 — 2026-08-27
- 8-K — 2026-08-26
- 10-Q — 2026-08-07
- 8-K — 2026-08-07
- 4 — 2026-08-04
- 4 — 2026-08-04
- 3 — 2026-08-04
- 3 — 2026-08-04
- EFFECT — 2026-08-03